Overview
Holmusk has published a peer-reviewed paper in Neuropsychiatric Disease and Treatment entitled, “Psychometric evaluation and linking of the PHQ-9, QIDS-C, and VQIDS-C in a real-world population with major depressive disorder.” This publication represents the first effort to link three commonly-used evaluation scales (PHQ-9, QIDS-C, and VQIDS-C) for assessing depressive symptoms in adult patients with non-psychotic major depressive disorder (MDD) using de-identified electronic health record-derived data, resulting in valuable conversion tables that can be used for research and to improve patient care.
Impact
MDD is a leading cause of disability worldwide and the accurate assessment of depressive symptomology is crucial for clinical management and research. The Patient Health Questionnaire-9 (PHQ-9), the clinician rated Quick Inventory of Depressive Symptomatology (QIDS-C), and the clinician rated 5-item Very Quick Inventory of Depressive Symptomatology (VQIDS-C) are widely used and validated tools to assess the prevalence and severity of depressive symptoms in patients with MDD. These scales are used both in clinical research and practice. Establishing a link between these scales has the potential to open up new opportunities for measurement integration, research collaboration, and improved patient care.
This study represents the first effort to link the PHQ-9, QIDS-C, and VQIDS-C in an adult population with non-psychotic MDD using real-world electronic health record data. Using statistical methods known as Classical Test Theory and Item Response Theory analyses, Holmusk researchers successfully developed conversion tables that clinicians and researchers can use in practice and research. The conversion tables can also be used to harness data from multiple sources to produce larger more representative cohorts for research studies and have already been integrated into the NeuroBlu Database.
To read the full manuscript, visit the journal online.
Palmer EOC, Ker S, Rentería ME, Carmody T, Rush AJ. Psychometric evaluation and linking of the PHQ-9, QIDS-C, and VQIDS-C in a real-world population with major depressive disorder. Neuropsychiatr Dis Treat. 2024;20:671-687https://doi.org/10.2147/NDT.S444223
